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Madrigal Pharmaceuticals, Inc. vs Ionis Pharmaceuticals Inc vs ANI Pharmaceuticals Inc vs Harmony Biosciences Holdings, Inc.

Latest annual figures from SEC filings. Each company is shown for its own most recent fiscal year, so period ends can differ. Select a figure to see its full history.

Latest fiscal yearMadrigal Pharmaceuticals, Inc.
MDGL		Ionis Pharmaceuticals Inc
IONS		ANI Pharmaceuticals Inc
ANIP		Harmony Biosciences Holdings, Inc.
HRMY
Year ended2025-12-312025-12-312025-12-312025-12-31
Revenue$958.40M$943.71M$883.37M$868.45M
Revenue growth (YoY)+432.1%+33.8%+43.8%+21.5%
Gross marginn/an/an/a77.2%
Operating margin-31.3%-40.4%12.6%24.0%
Net margin-30.1%-40.4%8.9%18.3%
Net income-$288.28M-$381.39M$78.34M$158.69M
EPS (Diluted)-$12.85-$2.38$3.32$2.71
Operating cash flow-$189.55M-$268.58M$185.22M$348.20M
Free cash flow-$190.02M-$320.03M$171.39M$347.89M
Cash & equivalents$198.69M$372.26M$285.58M$752.50M
Total assets$1.26B$3.52B$1.44B$1.27B
Total liabilities$656.90M$3.03B$899.65M$401.41M
Shareholders' equity$602.69M$489.09M$540.72M$870.22M
Return on year-end equity-47.8%-78.0%14.5%18.2%
Shares outstanding22.84M163.30M22.49M57.73M

n/a means the company did not report that line under the concept TickerFacts maps, not that it is zero.

Revenue, most recent five fiscal years

Fiscal yearMadrigal Pharmaceuticals, Inc.Ionis Pharmaceuticals IncANI Pharmaceuticals IncHarmony Biosciences Holdings, Inc.
Latest$958.40M
Ended 2025-12-31		$943.71M
Ended 2025-12-31		$883.37M
Ended 2025-12-31		$868.45M
Ended 2025-12-31
1 year earlier$180.13M
Ended 2024-12-31		$705.14M
Ended 2024-12-31		$614.38M
Ended 2024-12-31		$714.73M
Ended 2024-12-31
2 years earlier$0
Ended 2023-12-31		$787.65M
Ended 2023-12-31		$486.82M
Ended 2023-12-31		$582.02M
Ended 2023-12-31
3 years earlier$0
Ended 2022-12-31		$587.37M
Ended 2022-12-31		$316.38M
Ended 2022-12-31		$437.86M
Ended 2022-12-31
4 years earlier$0
Ended 2021-12-31		$810.46M
Ended 2021-12-31		$216.14M
Ended 2021-12-31		$305.44M
Ended 2021-12-31