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Ionis Pharmaceuticals Inc vs Madrigal Pharmaceuticals, Inc. vs ANI Pharmaceuticals Inc vs Harmony Biosciences Holdings, Inc.

Latest annual figures from SEC filings. Each company is shown for its own most recent fiscal year, so period ends can differ. Select a figure to see its full history.

Latest fiscal yearIonis Pharmaceuticals Inc
IONS		Madrigal Pharmaceuticals, Inc.
MDGL		ANI Pharmaceuticals Inc
ANIP		Harmony Biosciences Holdings, Inc.
HRMY
Year ended2025-12-312025-12-312025-12-312025-12-31
Revenue$943.71M$958.40M$883.37M$868.45M
Revenue growth (YoY)+33.8%+432.1%+43.8%+21.5%
Gross marginn/an/an/a77.2%
Operating margin-40.4%-31.3%12.6%24.0%
Net margin-40.4%-30.1%8.9%18.3%
Net income-$381.39M-$288.28M$78.34M$158.69M
EPS (Diluted)-$2.38-$12.85$3.32$2.71
Operating cash flow-$268.58M-$189.55M$185.22M$348.20M
Free cash flow-$320.03M-$190.02M$171.39M$347.89M
Cash & equivalents$372.26M$198.69M$285.58M$752.50M
Total assets$3.52B$1.26B$1.44B$1.27B
Total liabilities$3.03B$656.90M$899.65M$401.41M
Shareholders' equity$489.09M$602.69M$540.72M$870.22M
Return on year-end equity-78.0%-47.8%14.5%18.2%
Shares outstanding163.30M22.84M22.49M57.73M

n/a means the company did not report that line under the concept TickerFacts maps, not that it is zero.

Revenue, most recent five fiscal years

Fiscal yearIonis Pharmaceuticals IncMadrigal Pharmaceuticals, Inc.ANI Pharmaceuticals IncHarmony Biosciences Holdings, Inc.
Latest$943.71M
Ended 2025-12-31		$958.40M
Ended 2025-12-31		$883.37M
Ended 2025-12-31		$868.45M
Ended 2025-12-31
1 year earlier$705.14M
Ended 2024-12-31		$180.13M
Ended 2024-12-31		$614.38M
Ended 2024-12-31		$714.73M
Ended 2024-12-31
2 years earlier$787.65M
Ended 2023-12-31		$0
Ended 2023-12-31		$486.82M
Ended 2023-12-31		$582.02M
Ended 2023-12-31
3 years earlier$587.37M
Ended 2022-12-31		$0
Ended 2022-12-31		$316.38M
Ended 2022-12-31		$437.86M
Ended 2022-12-31
4 years earlier$810.46M
Ended 2021-12-31		$0
Ended 2021-12-31		$216.14M
Ended 2021-12-31		$305.44M
Ended 2021-12-31