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ANI Pharmaceuticals Inc vs Harmony Biosciences Holdings, Inc. vs Ionis Pharmaceuticals Inc vs Madrigal Pharmaceuticals, Inc.

Latest annual figures from SEC filings. Each company is shown for its own most recent fiscal year, so period ends can differ. Select a figure to see its full history.

Latest fiscal yearANI Pharmaceuticals Inc
ANIP		Harmony Biosciences Holdings, Inc.
HRMY		Ionis Pharmaceuticals Inc
IONS		Madrigal Pharmaceuticals, Inc.
MDGL
Year ended2025-12-312025-12-312025-12-312025-12-31
Revenue$883.37M$868.45M$943.71M$958.40M
Revenue growth (YoY)+43.8%+21.5%+33.8%+432.1%
Gross marginn/a77.2%n/an/a
Operating margin12.6%24.0%-40.4%-31.3%
Net margin8.9%18.3%-40.4%-30.1%
Net income$78.34M$158.69M-$381.39M-$288.28M
EPS (Diluted)$3.32$2.71-$2.38-$12.85
Operating cash flow$185.22M$348.20M-$268.58M-$189.55M
Free cash flow$171.39M$347.89M-$320.03M-$190.02M
Cash & equivalents$285.58M$752.50M$372.26M$198.69M
Total assets$1.44B$1.27B$3.52B$1.26B
Total liabilities$899.65M$401.41M$3.03B$656.90M
Shareholders' equity$540.72M$870.22M$489.09M$602.69M
Return on year-end equity14.5%18.2%-78.0%-47.8%
Shares outstanding22.49M57.73M163.30M22.84M

n/a means the company did not report that line under the concept TickerFacts maps, not that it is zero.

Revenue, most recent five fiscal years

Fiscal yearANI Pharmaceuticals IncHarmony Biosciences Holdings, Inc.Ionis Pharmaceuticals IncMadrigal Pharmaceuticals, Inc.
Latest$883.37M
Ended 2025-12-31		$868.45M
Ended 2025-12-31		$943.71M
Ended 2025-12-31		$958.40M
Ended 2025-12-31
1 year earlier$614.38M
Ended 2024-12-31		$714.73M
Ended 2024-12-31		$705.14M
Ended 2024-12-31		$180.13M
Ended 2024-12-31
2 years earlier$486.82M
Ended 2023-12-31		$582.02M
Ended 2023-12-31		$787.65M
Ended 2023-12-31		$0
Ended 2023-12-31
3 years earlier$316.38M
Ended 2022-12-31		$437.86M
Ended 2022-12-31		$587.37M
Ended 2022-12-31		$0
Ended 2022-12-31
4 years earlier$216.14M
Ended 2021-12-31		$305.44M
Ended 2021-12-31		$810.46M
Ended 2021-12-31		$0
Ended 2021-12-31