Company research / SPRO

Spero Therapeutics, Inc. (SPRO)

CIK 0001701108 · Nasdaq · Pharmaceutical Preparations

  • Sector Manufacturing
  • Incorporated DE
  • Fiscal year ends Dec 31

For the year ended 2025-12-31, Spero Therapeutics, Inc. reported revenue of $66.80M. Revenue grew 39.2% from the prior annual period. Over the twelve months to 2026-06-30, revenue was $47.00M.

Key ratios (year ended 2025-12-31)

9.5%
Operating margin
12.8%
Net margin
14.5%
Return on year-end equity
39.2%
Revenue growth (YoY)

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Latest selected filing: Form 8-K (current report) · 2026-08-28

Annual financials

Annual flows and balances are grouped by their actual period end. Select a figure to open its SEC filing. n/a means a matching observation is unavailable. Free cash flow is operating cash flow minus capital expenditures, and EBITDA is operating income plus depreciation and amortization, for the same period, computed by TickerFacts.

The first column covers the twelve months to 2026-06-30 from the latest quarterly report: flows are the last fiscal year plus this year to date minus the same months a year earlier, and balances are as of that date. Per-share figures are annual only.

Period endedTTM to
2026-06-30
2025-12-312024-12-312023-12-312022-12-312021-12-312020-12-312019-12-312018-12-312017-12-312016-12-31
Revenue$47.00M$66.80M$47.98M$103.78M$53.51M$18.26M$9.33M$18.15M$3.97M$1.98M$335.0K
R&D Expense$20.53M$38.47M$96.76M$51.44M$47.59M$64.53M$67.00M$65.78M$33.88M$32.87M$26.33M
Operating Income$6.03M$6.31M-$73.36M$21.48M-$42.20M-$87.97M-$79.11M-$63.22M-$42.81M-$41.73M-$33.22M
Depreciation & Amortizationn/a$0$2.0K$367.0K$869.0K$646.0K$761.0K$750.0K$409.0K$363.0K$279.0K
EBITDAn/a$6.31M-$73.36M$21.85M-$41.33M-$87.33M-$78.35M-$62.47M-$42.40M-$41.37M-$32.94M
Net Income$7.38M$8.57M-$68.57M$22.81M-$46.41M-$89.76M-$78.28M-$60.92M-$41.66M-$39.89M-$32.64M
EPS (Diluted)n/a$0.15-$1.27$0.43-$1.23-$2.91n/an/an/an/an/a
Total Assets$52.77M$68.92M$110.54M$182.39M$124.80M$171.07M$153.45M$106.10M$129.01M$93.48M$13.77M
Total Liabilities$8.56M$9.90M$64.42M$75.50M$48.87M$82.78M$21.41M$31.53M$13.15M$8.52M$7.41M
Shareholders' Equity$44.20M$59.02M$46.12M$106.89M$75.93M$88.29M$132.04M$74.57M$115.50M$84.60M-$45.44M
Cash & Equivalents$50.77M$40.27M$52.89M$76.33M$109.11M$112.58M$85.21M$29.73M$34.08M$87.29M$10.31M
Operating Cash Flow$19.58M-$12.62M-$23.44M-$32.99M-$7.73M-$64.35M-$85.87M-$50.02M-$39.62M-$39.11M-$28.96M
Capital Expendituresn/an/an/an/an/an/a$157.0K$314.0K$2.44M$27.0K$830.0K
Free Cash Flown/an/an/an/an/an/a-$86.03M-$50.33M-$42.06M-$39.14M-$29.79M
Shares Outstanding58.15M56.41M54.59M53.00M52.46M32.39M29.26M19.19M17.21M14.37Mn/a
Weighted Average Diluted Sharesn/a59.04M54.04M52.99M37.59M30.90Mn/an/an/an/an/a
EPS (Basic)n/a$0.15-$1.27$0.43-$1.23-$2.91n/an/an/an/an/a

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