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SYRE research notebook

Read the disclosures. Follow the relationships. Keep the dates in view.

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Download filings CSV

SEC submissions · retrieved 2026-09-07 · 8010 issuers; up to 32 recent company reports and 8 ownership-change filings per issuer

  1. 4 · Ownership change

    Report date 2026-09-01 · 0001636282-26-000111

  2. 4 · Ownership change

    Report date 2026-09-01 · 0001636282-26-000109

  3. 4 · Ownership change

    Report date 2026-09-01 · 0001636282-26-000107

  4. 8-K · Current report

    Report date 2026-08-25 · 0001636282-26-000105 · Items 7.01,8.01,9.01

  5. 4 · Ownership change

    Report date 2026-08-07 · 0001636282-26-000102

  6. 4 · Ownership change

    Report date 2026-08-03 · 0001636282-26-000100

  7. 4 · Ownership change

    Report date 2026-08-03 · 0001636282-26-000099

  8. 8-K · Current report

    Report date 2026-08-04 · 0001636282-26-000098 · Items 2.02,9.01

  9. 10-Q · Quarterly report

    Report date 2026-06-30 · 0001636282-26-000096

  10. 4 · Ownership change

    Report date 2026-07-01 · 0001636282-26-000088

  11. 4 · Ownership change

    Report date 2026-07-01 · 0001636282-26-000087

  12. 8-K · Current report

    Report date 2026-06-15 · 0001636282-26-000083 · Items 7.01,8.01,9.01

  13. 8-K · Current report

    Report date 2026-05-29 · 0001636282-26-000075 · Items 8.01,9.01

  14. 8-K · Current report

    Report date 2026-05-27 · 0001636282-26-000056 · Items 5.02,5.07,9.01

  15. 8-K · Current report

    Report date 2026-05-05 · 0001636282-26-000051 · Items 2.02,9.01

  16. 10-Q · Quarterly report

    Report date 2026-03-31 · 0001636282-26-000050

  17. 8-K · Current report

    Report date 2026-04-14 · 0001628280-26-025508 · Items 1.01,9.01

  18. 8-K · Current report

    Report date 2026-04-13 · 0001628280-26-024906 · Items 2.02,8.01

  19. 8-K · Current report

    Report date 2026-04-13 · 0001628280-26-024831 · Items 7.01,8.01,9.01

  20. DEF 14A · Proxy statement

    Report date 2026-05-27 · 0001636282-26-000039

  21. 8-K · Current report

    Report date 2026-02-19 · 0001636282-26-000022 · Items 2.02,9.01

  22. 10-K · Annual report

    Report date 2025-12-31 · 0001636282-26-000020

  23. 8-K · Current report

    Report date 2026-01-12 · 0001193125-26-009894 · Items 7.01,9.01

  24. 8-K · Current report

    Report date 2025-11-04 · 0001636282-25-000104 · Items 2.02,7.01,8.01,9.01

  25. 10-Q · Quarterly report

    Report date 2025-09-30 · 0001636282-25-000102

  26. 8-K · Current report

    Report date 2025-10-13 · 0001193125-25-240237 · Items 1.01,9.01

  27. 8-K · Current report

    Report date 2025-10-14 · 0001193125-25-237904 · Items 2.02

  28. 8-K · Current report

    Report date 2025-08-05 · 0001636282-25-000091 · Items 2.02,9.01

  29. 10-Q · Quarterly report

    Report date 2025-06-30 · 0001636282-25-000089

  30. 8-K · Current report

    Report date 2025-06-17 · 0001193125-25-141756 · Items 7.01,8.01,9.01

  31. 8-K · Current report

    Report date 2025-05-29 · 0001636282-25-000063 · Items 5.07,9.01

  32. 8-K · Current report

    Report date 2025-05-08 · 0001636282-25-000050 · Items 2.02,9.01

  33. 10-Q · Quarterly report

    Report date 2025-03-31 · 0001636282-25-000049

  34. DEF 14A · Proxy statement

    Report date 2025-05-29 · 0001636282-25-000038

  35. 8-K · Current report

    Report date 2025-02-28 · 0001193125-25-048423 · Items 4.01,9.01

  36. 8-K · Current report

    Report date 2025-02-27 · 0001636282-25-000022 · Items 2.02,9.01

  37. 10-K · Annual report

    Report date 2024-12-31 · 0001636282-25-000020

  38. 8-K · Current report

    Report date 2025-01-13 · 0001193125-25-005015 · Items 2.02,8.01,9.01

  39. 8-K · Current report

    Report date 2024-11-18 · 0001628280-24-048527 · Items 1.01,9.01

  40. 10-Q/A · Quarterly report

    Report date 2024-09-30 · 0001636282-24-000113

Reported insider transactions

Download transactions CSV

SEC insider transactions · retrieved 2026-09-07 · 2026 Q2: filings in this completed quarter; not a live transaction feed

Purchases and sales include open-market or private transactions. Grants, exercises and tax withholding are shown separately. Amendments and joint reports can overlap; rows are not a net-buying score. Prices retain the filing's units; consult its footnotes.

Transaction rows by code · counts, not monetary totals
Purchase: 0 transaction rows0PSale: 34 transaction rows34SGrant / award: 6 transaction rows6AExercise / conversion: 14 transaction rows14MTax / exercise payment: 0 transaction rows0FGift: 0 transaction rows0G
P · PurchaseS · SaleA · Grant / awardM · Exercise / conversionF · Tax / exercise paymentG · Gift

56 matching transaction rows. Showing 1–50.

Transaction / filedReporting ownerTypeSecuritySharesReported price
2026-06-25
2026-06-26
Burrows Scott LS · Sale
Disposed
Common Stock5000.087.12
2026-06-25
2026-06-26
Burrows Scott LS · Sale
Disposed
Common Stock10000.087.14
2026-06-25
2026-06-26
Burrows Scott LM · Exercise / conversion
Acquired
Common Stock15000.014.5
2026-06-25
2026-06-26
Burrows Scott LM · Exercise / conversion
Disposed
Stock Option (Right to Buy)
Derivative security
15000.00.0
2026-06-23
2026-06-23
Fairmount Funds Management LLC; Fairmount Healthcare Fund II L.P.; Harwin Peter Evan; Kiselak TomasC · Conversion
Acquired
Common Stock666680.0—
2026-06-23
2026-06-23
Fairmount Funds Management LLC; Fairmount Healthcare Fund II L.P.; Harwin Peter Evan; Kiselak TomasS · Sale
Disposed
Common Stock4684781.085.31
2026-06-23
2026-06-23
Fairmount Funds Management LLC; Fairmount Healthcare Fund II L.P.; Harwin Peter Evan; Kiselak TomasC · Conversion
Disposed
Series B Preferred Stock
Derivative security
16667.00.0
2026-06-22
2026-06-23
HENDERSON MICHAEL THOMAS
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock20000.0100.0
2026-06-03
2026-06-03
Sloan Sheldon
10b5-1 checkbox reported
M · Exercise / conversion
Acquired
Common Stock8333.027.46
2026-06-03
2026-06-03
Sloan Sheldon
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock8333.075.0
2026-06-03
2026-06-03
Sloan Sheldon
10b5-1 checkbox reported
M · Exercise / conversion
Disposed
Stock Option (Right to Buy)
Derivative security
8333.00.0
2026-06-01
2026-06-03
Turtle Cameron
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock3294.071.38
2026-06-01
2026-06-03
Turtle Cameron
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock8149.070.5
2026-06-01
2026-06-03
Turtle Cameron
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock3557.069.4
2026-06-01
2026-06-03
Burrows Scott L
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock3100.072.06
2026-06-01
2026-06-03
Burrows Scott L
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock2599.070.77
2026-06-01
2026-06-03
Burrows Scott L
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock1801.069.75
2026-06-01
2026-06-03
Burrows Scott L
10b5-1 checkbox reported
M · Exercise / conversion
Acquired
Common Stock7500.014.5
2026-06-01
2026-06-03
Burrows Scott L
10b5-1 checkbox reported
M · Exercise / conversion
Disposed
Stock Option (Right to Buy)
Derivative security
7500.00.0
2026-05-27
2026-05-29
Milligan SandraA · Grant / award
Acquired
Stock Option (Right to Buy)
Derivative security
8026.00.0
2026-05-27
2026-05-29
Fairmount Funds Management LLC; Fairmount Healthcare Fund II L.P.; Kiselak TomasA · Grant / award
Acquired
Stock Option (Right to Buy)
Derivative security
8026.00.0
2026-05-27
2026-05-29
Albers Jeffrey W.A · Grant / award
Acquired
Stock Option (Right to Buy)
Derivative security
8026.00.0
2026-05-27
2026-05-29
HENDERSON MICHAEL THOMASA · Grant / award
Acquired
Stock Option (Right to Buy)
Derivative security
8026.00.0
2026-05-27
2026-05-29
Stelzer LaurieA · Grant / award
Acquired
Stock Option (Right to Buy)
Derivative security
8026.00.0
2026-05-27
2026-05-29
McKenna Mark C.A · Grant / award
Acquired
Stock Option (Right to Buy)
Derivative security
8026.00.0
2026-05-08
2026-05-08
HENDERSON MICHAEL THOMAS
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock2404.072.57
2026-05-08
2026-05-08
HENDERSON MICHAEL THOMAS
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock24814.074.76
2026-05-08
2026-05-08
HENDERSON MICHAEL THOMAS
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock19269.075.35
2026-05-08
2026-05-08
HENDERSON MICHAEL THOMAS
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock33513.073.72
2026-05-01
2026-05-01
Sloan Sheldon
10b5-1 checkbox reported
M · Exercise / conversion
Acquired
Common Stock78333.027.46
2026-05-01
2026-05-01
Sloan Sheldon
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock5059.074.6
2026-05-01
2026-05-01
Sloan Sheldon
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock10358.073.74
2026-05-01
2026-05-01
Sloan Sheldon
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock12777.072.94
2026-05-01
2026-05-01
Sloan Sheldon
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock8777.071.56
2026-05-01
2026-05-01
Sloan Sheldon
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock19656.070.61
2026-05-01
2026-05-01
Sloan Sheldon
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock400.075.37
2026-05-01
2026-05-01
Sloan Sheldon
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock21306.069.53
2026-05-01
2026-05-01
Sloan Sheldon
10b5-1 checkbox reported
M · Exercise / conversion
Disposed
Stock Option (Right to Buy)
Derivative security
78333.00.0
2026-05-01
2026-05-01
Burrows Scott L
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock12500.071.37
2026-05-01
2026-05-01
Burrows Scott L
10b5-1 checkbox reported
M · Exercise / conversion
Acquired
Common Stock12500.014.5
2026-05-01
2026-05-01
Burrows Scott L
10b5-1 checkbox reported
M · Exercise / conversion
Disposed
Stock Option (Right to Buy)
Derivative security
12500.00.0
2026-05-01
2026-05-01
Turtle Cameron
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock3100.073.14
2026-05-01
2026-05-01
Turtle Cameron
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock1000.071.76
2026-05-01
2026-05-01
Turtle Cameron
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock3600.070.77
2026-05-01
2026-05-01
Turtle Cameron
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock5300.069.54
2026-05-01
2026-05-01
Turtle Cameron
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock300.074.96
2026-05-01
2026-05-01
Turtle Cameron
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock1700.074.23
2026-04-01
2026-04-03
Burrows Scott L
10b5-1 checkbox reported
M · Exercise / conversion
Acquired
Common Stock7500.014.5
2026-04-01
2026-04-03
Burrows Scott L
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock6200.049.21
2026-04-01
2026-04-03
Burrows Scott L
10b5-1 checkbox reported
S · Sale
Disposed
Common Stock1300.049.98

Identity & relationships

Wikidata structured data · retrieved 2026-09-07 · 1611 unambiguous CIK-linked entities; coverage is incomplete

These are sourced identity and relationship claims, with incomplete coverage. Headquarters locations do not describe sales, assets or operating exposure.

SEC issuer · 0001636282Spyre Therapeutics, Inc.

No parent relationship is available in this import; this is not proof of independence.

No verified LEI join available.

GLEIF legal entity reference data · retrieved 2026-09-07 · 1177 checked identities; 0 unavailable records

Search names and former names

View Wikidata identity and references ↗

  • Aeglea BioTherapeutics · alias · wikidata
  • Aeglea BioTherapeutics Inc. · alias · wikidata
  • Aeglea BioTherapeutics, Inc. · former SEC name · 2015-03-24 to 2023-11-24
Explore headquarters map ↗

Revenue in constant purchasing power

USD revenue expressed in 2026-07 consumer-price dollars. Each annual period uses a CPI-U average weighted by the days in its actual reporting interval. This is a purchasing-power comparison, not a company-specific price or volume measure.

Year endedReported USD revenueCPI-adjusted USD revenue
2024-12-31$0$0
2023-12-31$886.0K$970.9K
2022-12-31$2.33M$2.66M
2021-12-31$18.74M$23.09M
2020-12-31$0$0
2019-12-31$0$0
2018-12-31$3.89M$5.17M
2017-12-31$5.21M$7.09M

Bureau of Labor Statistics · retrieved 2026-09-07 · 9 selected series; gaps remain missing

Explore the CPI history ↗